How can depression develop?
What biological, psychological and social factors can contribute to depression?
WHO describes an interaction of social, psychological and biological factors. The German guideline also considers several levels of explanation. One trigger does not automatically explain the entire condition. [1][2]
General information for adults. Not medical or psychotherapeutic advice; not a substitute for examination, diagnosis or treatment.
Sources & editorial status
- WHO: Depressive disorder (depression) ↗
International overview. Used for the distinction from mood changes and contributing factors.
- German depression guideline: Background (in German) ↗
German clinical guideline, background and risk factors; population-level relationships do not determine an individual cause. Accessed: 29 October 2026.
Compiled from an existing article: 31 October 2026. Source comparison in the article: 29 October 2026. Prepared with AI assistance; independent medical review is pending. Editorial compilation; independent medical expert review has not taken place.
Editorial responsibility: Mario V.W.B.R. Obst. Known limitations and the use of each source are explained alongside the reference. A source-comparison date is not the publication date of the original source.